EVALUATION OF SERUM PROTEIN LEVELS AND CIC LEVELS IN PATIENTS WITH CEREBRAL MALARIA
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- Qualitative
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- Recommended for : Educators
- NGN 3000
INTRODUCTION
Globally, Malaria is likely one of the first illnesses known to humans and has had a significant influence on the development of our culture. According to Margret & Suzzan (2019), the history of malaria and the horrific consequences it has on humans goes back to the beginning of civilization, making it an integral part of the history of mankind. This age-old illness continues to be a problem in tropical and subtropical regions today. There are tens of cases of Ilion reported each year in endemic zones around the world, including Africa, the Middle East, Asia and China, and Central and South America (Lucas, 1992).
Malaria is an infectious disease that causes fever in addition to a host of other symptoms (WHO 2018). It is a disease that is caused by a blood-borne protozoan parasite that is an intracellular parasite belonging to the class Sporozoa and of the genus Plasmodium, and it is transmitted by the bite of an infected female anopheles mosquito. Center for Disease and Control (2019) opined that There are four distinct parasites that belong to this genus that have the potential to cause malaria in humans. Plasmodium falciparum is one of the genera that cause malaria, and it is responsible for the most severe and dangerous form of the illness. It is also the only species that may induce acute ality. Plasmodium falciparum will be the primary focus of this research since it is the most common form of malaria in Nigeria. Malaria parasites belonging to this genus spend part of their life cycle in the red cells of the host, which is where the erythrocyticschizogony takes place. They eventually transform into merozoites and proceed through a cycle that results in the production of schizonts. When a red cell ruptures, it releases merozoites into the circulation. These merozoites then infect new red cells, which triggers an immunological response. Each cycle comes to an end when this happens.
Onyedika & Kelechi (2019) opined that an infection with malaria causes the development of immune complexes that then circulate in the blood. For a good many years, research has been focused on determining the significance of circulating immune complexes (CIC) and how these complexes are connected to a wide range of disorders. In an immune system that is healthy and operating regularly, the formation of immune complexes is a defensive, ongoing process that is often harmless. However, in some people CIC are deposited in the walls of blood vessels, particularly in the glomerular capillaries, which is where they are responsible for the harm they cause to tissue. The creation of immunological complexes, also known as antigen-antibody complexes (AgAb), is caused by the biospecific binding that takes place between the sites of the antibody and the determinant group of the antigen (McDougal and McDuffie, 1985). Because it is known that malaria can lead to death, the purpose of this study is to evaluate the extent of the circulating immune complexes as well as a few biochemical markers. These biochemical measures include serum total rein, albumin, and globulin.
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